1. When you are asked if you can do a job, tell 'em, 'Certainly I can!' Then get busy and find out how to do it. - Theodore Roosevelt
2. Whether women are better than men I cannot say - but I can say they are certainly no worse. - Golda Meir
3. I like living. I have sometimes been wildly, despairingly, acutely miserable, racked with sorrow, but through it all I still know quite certainly that just to be alive is a grand thing. - Agatha Christie
4. I am what time, circumstance, history, have made of me, certainly, but I am also, much more than that. So are we all. - James Baldwin
5. Educate the masses, elevate their standard of intelligence, and you will certainly have a successful nation. Alexander - Graham Bell
6. I am what time, circumstance, history, have made of me, certainly, but I am also, much more than that. So are we all. - James Baldwin
7. I will seize fate by the throat; it shall certainly never wholly overcome me. - Ludwig van Beethoven
8. The atomic bomb certainly is the most powerful of all weapons, but it is conclusively powerful and effective only in the hands of the nation which controls the sky. - Lyndon B. Johnson
9. At some future period, not very distant as measured by centuries, the civilized races of man will almost certainly exterminate, and replace the savage races throughout the world. - Charles Darwin
10. People don't understand that when I grew up, I was never the most talented. I was never the biggest. I was never the fastest. I certainly was never the strongest. The only thing I had was my work ethic, and that's been what has gotten me this far. - Tiger Woods
11. They certainly give very strange names to diseases. - Plato
12. We're all caught up in circumstances, and we're all good and evil. When you're really hungry, for instance, you'll do anything to survive. I think the most evil thing - well, maybe that's too strong - but certainly a very evil thing is judgment, the sin of ignorance. - Anthony Hopkins.
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Summary
Walter Gilbert (born March 21, 1932, Boston, Mass., U.S.) is an American molecular biologist who was awarded a share (with Paul Berg and Frederick Sanger) of the Nobel Prize for Chemistry in 1980 for his development of a method for determining the sequence of nucleotide links in the chainlike molecules of nucleic acids (DNA and RNA).
Gilbert graduated from Harvard University with a degree in physics in 1953 and took a Ph.D. in mathematics from Cambridge University in 1957. He joined the Harvard faculty as a lecturer in physics in 1958 and, as his interests changed, advanced to assistant professor of physics in 1959, associate professor of biophysics in 1964, and professor of biochemistry in 1968. In 1974 he became American Cancer Society Professor of Molecular Biology at Harvard.
In the late 1960s Gilbert confirmed the theory of Jacques Monod and Franƈois Jacob that “repressor proteins” control the genes responsible for beginning and ending protein synthesis in the cell. He was able to demonstrate the existence of a repressor in the bacterium Escherichia coli that prevents a gene from manufacturing a certain enzyme except when lactose is present. In the 1970s Gilbert developed a widely used technique of using gel electrophoresis to read the nucleotide sequences of DNA segments. The same method was developed independently by Sanger.
In 1979 Gilbert, while retaining his affiliation with Harvard, joined a group of other scientists and businessmen to form Biogen, a commercial genetic-engineering research corporation. Gilbert resigned from Biogen in 1985 and, while continuing to teach at Harvard, became a chief proponent of the Human Genome Project, a government-funded effort to compile a complete map of the gene sequences in human DNA. He became emeritus at Harvard in 1987.
Gilbert founded Myriad Genetics in 1992 and served as director and vice chairman of the board. He helped to found Paratek Pharmaceuticals (1996), a company invested in combatting bacterial resistance, and Memory Pharmaceuticals (1998), which was geared toward developing cures for central nervous system disorders. Gilbert was also managing director of BioVentures Investors, where he became a partner in 2001. He served on the advisory boards of several other biotechnology companies as well.
Details
Walter Gilbert (born March 21, 1932) is an American biochemist, physicist, molecular biology pioneer, and Nobel laureate.
Education and early life
Walter Gilbert was born in Boston, Massachusetts, on March 21, 1932, into a Jewish family, the son of Emma (Cohen), a child psychologist, and Richard V. Gilbert, an economist.
When Gilbert was seven years old, the family moved to the Washington D.C. area so his father could work under Harry Hopkins on the New Deal brain trust. While living in Washington the family became friends with the family of I.F. Stone and Wally met Stone's oldest daughter, Celia, when they were both 8. They later married at age 21.
He was educated at the Sidwell Friends School, and attended Harvard University for undergraduate and graduate studies, earning a baccalaureate in chemistry and physics in 1953 and a master's degree in physics in 1954. He studied for his doctorate at the University of Cambridge, where he earned a PhD in physics supervised by the Nobel laureate Abdus Salam in 1957.
Career and research
Gilbert returned to Harvard in 1956 and was appointed assistant professor of physics in 1959. Gilbert's wife Celia worked for James Watson, leading Gilbert to become interested in molecular biology. Watson and Gilbert ran their laboratory jointly through most of the 1960s, until Watson left for Cold Spring Harbor Laboratory. In 1964 he was promoted to associate professor of biophysics and promoted again in 1968 to professor of biochemistry.
Gilbert is a co-founder of the biotech start-up companies Biogen, with Kenneth Murray, Phillip Sharp and Charles Weissman and Myriad Genetics with Dr. Mark Skolnick and Kevin Kimberlin where he was the first chairman on their respective boards of directors. Gilbert left his position at Harvard to run Biogen as CEO, but was later asked to resign by the company's board of directors. He is a member of the Board of Scientific Governors at The Scripps Research Institute. Gilbert has served as the chairman of the Harvard Society of Fellows.
In 1996, Gilbert and Stuart B. Levy founded Paratek Pharmaceuticals. Gilbert served as chairman until 2014.
Gilbert was an early proponent of sequencing the human genome. At a March 1986 meeting in Santa Fe New Mexico he proclaimed "The total human sequence is the grail of human genetics". In 1987, he proposed starting a company called Genome Corporation to sequence the genome and sell access to the information. In an opinion piece in Nature in 1991, he envisioned completion of the human genome sequence transforming biology into a field in which computer databases would be as essential as laboratory reagents.
Gilbert returned to Harvard in 1985. Gilbert was an outspoken critic of David Baltimore in the handling of the scientific fraud accusations against Thereza Imanishi-Kari. Gilbert also joined the early controversy over the cause of AIDS. In 1962, Gilbert's PhD student in physics Gerald Guralnik extended Gilbert's work on massless particles; Guralnik's work on is widely recognized as an important thread in the discovery of the Higgs Boson.
With his PhD student Benno Müller-Hill, Gilbert was the first to purify the lac repressor, just beating out Mark Ptashne for purifying the first gene regulatory protein.
Together with Allan Maxam, Gilbert developed a new DNA sequencing method, Maxam–Gilbert sequencing, using chemical methods developed by Andrei Mirzabekov. His approach to the first synthesis of insulin via recombinant DNA lost out to Genentech's approach which used genes built up from the nucleotides rather than from natural sources. Gilbert's effort was hampered by a temporary moratorium on recombinant DNA work in Cambridge, Massachusetts, forcing his group to move their work to an English biological weapons site.
Gilbert first proposed the existence of introns and exons and explained the evolution of introns in a seminal 1978 "News and Views" paper published in Nature. In 1986, Gilbert proposed the RNA world hypothesis for the origin of life, based on a concept first proposed by Carl Woese in 1967.
Awards and honors
In 1969, Gilbert was awarded Harvard's Ledlie Prize. In 1972 he was named American Cancer Society Professor of Molecular Biology. In 1979, Gilbert was awarded the Louisa Gross Horwitz Prize from Columbia University together with Frederick Sanger. That year he was also awarded the Gairdner Prize and the Albert Lasker Award for Basic Medical Research.
Gilbert was awarded the 1980 Nobel Prize in Chemistry, shared with Frederick Sanger and Paul Berg. Gilbert and Sanger were recognized for their pioneering work in devising methods for determining the sequence of nucleotides in a nucleic acid.
Gilbert has also been honored by the National Academy of Sciences (US Steel Foundation Award, 1968); Massachusetts General Hospital (Warren Triennial Prize, 1977); the New York Academy of Sciences; (Louis and Bert Freedman Foundation Award, 1977), the Académie des Sciences of France (Prix Charles-Leopold Mayer Award, 1977). Gilbert was elected a Foreign Member of the Royal Society (ForMemRS) in 1987.
In 2002, he received the Biotechnology Heritage Award, from the Biotechnology Industry Organization (BIO) and the Chemical Heritage Foundation.
Allan Maxam and Walter Gilbert's 1977 paper "A new method for sequencing DNA" was honored by a Citation for Chemical Breakthrough Award from the Division of History of Chemistry of the American Chemical Society for 2017. It was presented to the Department of Molecular & Cellular Biology, Harvard University.
Personal life
Gilbert married Celia Stone, the daughter of I. F. Stone, in 1953 and has two children. After retiring from Harvard in 2001, Gilbert has launched an artistic career to combine art and science. His art format is centered on digital photography.
Additional Information
An organism's genome is stored in the form of long rows of building blocks, known as nucleotides, which form DNA molecules. An organism's genome can be mapped by establishing the order of the nucleotides within the DNA molecule. In 1976, Allan Maxam and Walter Gilbert developed a method by which the ends of the DNA molecule could be marked using radioactive substances. After undergoing treatment with small amounts of chemicals that react with specific nucleotides, DNA fragments of varying lengths can be obtained. After undergoing what is known as electrophoresis, the nucleotide sequences in a DNA sample can be identified.
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1. We all sort of do want incentives for creative people to still exist at a certain level. You know, maybe rock stars shouldn't make as much; who knows? But you want as much creativity to take place in the future as took place in the past. - Bill Gates
2. Nine-tenths of tactics are certain, and taught in books: but the irrational tenth is like the kingfisher flashing across the pool, and that is the test of generals. - T. E. Lawrence
3. It just seems like a religion that is perfect for people who feel like they need a grounding, who feels that the world has run off on them. I've discussed this with Scientologists, and they don't disagree. So, for a certain type of person, that's great. - Russell Crowe
4. I am saying this with a certain sense of confidence and not arrogance. The defence ministry is being run without any middleman and in a transparent way. We have proved that defence procurement can happen without middlemen. - Nirmala Sitharaman
5. I never thought I'd have children; I never thought I'd be in love, I never thought I'd meet the right person. Having come from a broken home - you kind of accept that certain things feel like a fairy tale, and you just don't look for them. - Angelina Jolie
6. So far as hypotheses are concerned, let no one expect anything certain from astronomy, which cannot furnish it, lest he accept as the truth ideas conceived for another purpose, and depart from this study a greater fool than when he entered it. - Nicolaus Copernicus
7. Any politician is to a certain degree a mentor. They preach something. - Dmitry Medvedev
8. With any recovery from morbidity there must go a certain healthy humiliation. - Gilbert K. Chesterton
9. The love in the old days had a certain grace, quintessential feel to it. Now everybody is busy in their phones. - Jackie Shroff
10. Truthfully, I'm proud of each of my films in a certain way. - Chuck Norris
11. The challenge itself is to exceed certain high standards you've set for yourself. - Dimple Kapadia
12. If we have an atom that is in an excited state and so is going to emit a photon, we cannot say when it will emit the photon. It has a certain amplitude to emit the photon at any time, and we can predict only a probability for emission; we cannot predict the future exactly. - Richard P. Feynman
13. I had this sort of idolatry for certain actors who preceded me, people who inspired me, so I'm honored to be that way for young actors. - Meryl Streep
14. Once you have a computer that can do a few things - strictly speaking, one that has a certain 'sufficient set' of basic procedures - it can do basically anything any other computer can do. This, loosely, is the basis of the great principle of 'Universality'. - Richard P. Feynman.
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1. Adventure upon all the tickets in the lottery, and you lose for certain; and the greater the number of your tickets the nearer your approach to this certainty. - Adam Smith
2. Great is truth, but still greater, from a practical point of view, is silence about truth. By simply not mentioning certain subjects... totalitarian propagandists have influenced opinion much more effectively than they could have by the most eloquent denunciations. - Aldous Huxley
3. Beyond a certain point, the music isn't mine anymore. It's yours. - Phil Collins
4. I realise that in this undertaking I place myself in a certain opposition to views widely held concerning the mathematical infinite and to opinions frequently defended on the nature of numbers. - Georg Cantor
5. We are the creative force of our life, and through our own decisions rather than our conditions, if we carefully learn to do certain things, we can accomplish those goals. - Stephen Covey
6. Organic compounds exist in which a hydrogen atom, joined to the carbon, acquires acid properties as a result of the proximity of certain functional groupings. - Victor Grignard
7. We're going to be able to ask our computers to monitor things for us, and when certain conditions happen, are triggered, the computers will take certain actions and inform us after the fact. - Steve Jobs
8. There is nothing on earth that could ever make me want to relive certain years of my life when I was young. - Johnny Depp
9. Gain may be temporary and uncertain; but ever while you live, expense is constant and certain: and it is easier to build two chimneys than to keep one in fuel. - Benjamin Franklin
10. Specialized meaninglessness has come to be regarded, in certain circles, as a kind of hallmark of true science. - Aldous Huxley
11. A tragedy is a representation of an action that is whole and complete and of a certain magnitude. A whole is what has a beginning and middle and end. - Aristotle
12. I think a certain amount of stress in life is good. The stress of just working, which takes effort - I think it keeps you going. - Anthony Hopkins.
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1. I'm a catalyst for change. You can't be an outsider and be successful over 30 years without leaving a certain amount of scar tissue around the place. - Rupert Murdoch
2. Civil disobedience has an honourable history, and when the urgency and moral clarity cross a certain threshold, then I think that civil disobedience is quite understandable, and it has a role to play. - Al Gore
3. I can easily conceive, most Holy Father, that as soon as some people learn that in this book which I have written concerning the revolutions of the heavenly bodies, I ascribe certain motions to the Earth, they will cry out at once that I and my theory should be rejected. - Nicolaus Copernicus
4. I realise that in this undertaking I place myself in a certain opposition to views widely held concerning the mathematical infinite and to opinions frequently defended on the nature of numbers. - Georg Cantor
5. Well, you know, a lot of people look at the negative things, the things that they did wrong and - which I do. But I like to stress on the things I did right, because there are certain things that I like to look at from a positive standpoint that are just positive reinforcement. - Tiger Woods
6. In spite of the opinions of certain narrow-minded people, who would shut up the human race upon this globe, as within some magic circle it must never outstep, we shall one day travel to the moon, the planets, and the stars, with the same facility, rapidity, and certainty as we now make the voyage from Liverpool to New York! - Jules Verne
7. Quite often in acting, you have to play a certain part; you cannot speak as much as you want to speak. - Sylvester Stallone
8. There is a certain sense in which I would say the universe has a purpose. It's not there by chance. - Roger Penrose
9. Certain people in the United States are driving nails into this structure of our relationship, then cutting off the heads. So the Soviets must use their teeth to pull them out. - Mikhail Gorbachev
10. As far as the laws of mathematics refer to reality, they are not certain, and as far as they are certain, they do not refer to reality. - Albert Einstein.
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1. I realise that in this undertaking I place myself in a certain opposition to views widely held concerning the mathematical infinite and to opinions frequently defended on the nature of numbers. - Georg Cantor
2. In spite of the opinions of certain narrow-minded people, who would shut up the human race upon this globe, as within some magic circle it must never outstep, we shall one day travel to the moon, the planets, and the stars, with the same facility, rapidity, and certainty as we now make the voyage from Liverpool to New York! - Jules Verne
3. For time and the world do not stand still. Change is the law of life. And those who look only to the past or the present are certain to miss the future. - John F. Kennedy
4. There is a certain sense in which I would say the universe has a purpose. It's not there by chance. - Roger Penrose
5. Certain people in the United States are driving nails into this structure of our relationship, then cutting off the heads. So the Soviets must use their teeth to pull them out. - Mikhail Gorbachev
6. As far as the laws of mathematics refer to reality, they are not certain, and as far as they are certain, they do not refer to reality. - Albert Einstein
7. We're going to be able to ask our computers to monitor things for us, and when certain conditions happen, are triggered, the computers will take certain actions and inform us after the fact. - Steve Jobs
8. If you're treated a certain way you become a certain kind of person. If certain things are described to you as being real they're real for you whether they're real or not. - James Baldwin
9. We always live in an uncertain world. What is certain is that the United States will go forward over time. - Warren Buffett
10. What the statesman is most anxious to produce is a certain moral character in his fellow citizens, namely a disposition to virtue and the performance of virtuous actions. - Aristotle
11. We are the creative force of our life, and through our own decisions rather than our conditions, if we carefully learn to do certain things, we can accomplish those goals. - Stephen Covey
12. 'Tis very certain the desire of life prolongs it. - Lord Byron.
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1. I mean, I do think at a certain point you've made enough money. - Barack Obama
2. You learn something out of everything, and you come to realize more than ever that we're all here for a certain space of time, and, and then it's going to be over, and you better make this count. - Nancy Reagan
3. If a man consults whether he is to fight, when he has the power in his own hands, it is certain that his opinion is against fighting. - Horatio Nelson
4. Perhaps no person can be a poet, or even enjoy poetry, without a certain unsoundness of mind. - Thomas Babington Macaulay
5. Beyond a certain point, the music isn't mine anymore. It's yours. - Phil Collins
6. Adventure upon all the tickets in the lottery, and you lose for certain; and the greater the number of your tickets the nearer your approach to this certainty. - Adam Smith
7. Women have a certain sexuality, and I think their bodies are beautiful, and I'm not embarrassed to explore that in a film. But there are things you get offered that are vulgar and violent - just like there's a side of me that's vulgar and violent. - Angelina Jolie
8. There's a drive in me that won't allow me to do certain things that are easy. - Johnny Depp
9. The whole history of science has been the gradual realization that events do not happen in an arbitrary manner, but that they reflect a certain underlying order, which may or may not be divinely inspired. - Stephen Hawking
10. Men do not understand books until they have a certain amount of life, or at any rate no man understands a deep book, until he has seen and lived at least part of its contents. - Ezra Pound
11. It is a grand mistake to think of being great without goodness and I pronounce it as certain that there was never a truly great man that was not at the same time truly virtuous. - Benjamin Franklin
12. Well, you know, a lot of people look at the negative things, the things that they did wrong and - which I do. But I like to stress on the things I did right, because there are certain things that I like to look at from a positive standpoint that are just positive reinforcement. - Tiger Woods.
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1. All men having power ought to be distrusted to a certain degree. - James Madison
2. We'd all like to be certain of what we know, but I think the most important question is to ask yourself do you really know what you know? - Marlon Brando
3. Badly constructed houses do for the healthy what badly constructed hospitals do for the sick. Once insure that the air in a house is stagnant, and sickness is certain to follow. - Florence Nightingale
4. A certain degree of neurosis is of inestimable value as a drive, especially to a psychologist. - Sigmund Freud
5. I suppose when they reach a certain age some men are afraid to grow up. It seems the older the men get, the younger their new wives get. - Elizabeth Taylor
6. The - the early Rockefellers made their wealth from being in certain businesses and - and remained personally very wealthy. Tatas were different in the sense the future generations were not so wealthy. They - they were involved in the business, but most of the family wealth is put into trust, and the family did not, in fact, enjoy enormous wealth. - Ratan Tata
7. The wise man does not expose himself needlessly to danger, since there are few things for which he cares sufficiently; but he is willing, in great crises, to give even his life - knowing that under certain conditions it is not worthwhile to live. - Aristotle
8. I am someone who can't hold on to negativity or hold on to grudges. I might feel something at a certain point, but I get tired after that. I don't carry it with me. I forgive and forget very easily, and that's the only way to be happy and peaceful. - Deepika Padukone
9. I seriously feel like the best days are ahead, and I like the idea of getting to do everything I did before but with more knowledge, experience, and street smarts. There's a certain love, appreciation, and gratitude that you have at 40 that you don't have when you're younger, and it makes every accomplishment feel so much better. - Jennifer Lopez
10. If we must not act save on a certainty, we ought not to act on religion, for it is not certain. But how many things we do on an uncertainty, sea voyages, battles! - Blaise Pascal
11. Nine-tenths of tactics are certain, and taught in books: but the irrational tenth is like the kingfisher flashing across the pool, and that is the test of generals. - T. E. Lawrence
12. Ever since I started to get recognition I've picked out certain fans and reverse-stalked them. - Jim Carrey.
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1. All thought must, directly or indirectly, by way of certain characters, relate ultimately to intuitions, and therefore, with us, to sensibility, because in no other way can an object be given to us. - Immanuel Kant
2. There are certain shades of limelight that can wreck a girl's complexion. - Audrey Hepburn
3. Sometimes, wearing a scarf and a polo coat and no makeup and with a certain attitude of walking, I go shopping or just look at people living. But then, you know, there will be a few teenagers who are kind of sharp, and they'll say, 'Hey, just a minute. You know who I think that is?' And they'll start tailing me. And I don't mind. - Marilyn Monroe
4. To be absolutely certain about something, one must know everything or nothing about it. - Henry Kissinger
5. Advertising works most effectively when it's in line with what people are already trying to do. And people are trying to communicate in a certain way on Facebook - they share information with their friends, they learn about what their friends are doing - so there's really a whole new opportunity for a new type of advertising model within that. - Mark Zuckerberg
6. Gravity must be caused by an Agent acting constantly according to certain laws, but whether this Agent be material or immaterial I have left to the consideration of my readers. - Isaac Newton
7. This is certain, that a man that studieth revenge keeps his wounds green, which otherwise would heal and do well. - Francis Bacon
8. The only certain freedom's in departure. - Robert Frost
9. To be fond of dancing was a certain step towards falling in love. - Jane Austen
10. I can easily conceive, most Holy Father, that as soon as some people learn that in this book which I have written concerning the revolutions of the heavenly bodies, I ascribe certain motions to the Earth, they will cry out at once that I and my theory should be rejected. - Nicolaus Copernicus
11. Certain defects are necessary for the existence of individuality. - Johann Wolfgang von Goethe
12. The propagandist's purpose is to make one set of people forget that certain other sets of people are human. - Aldous Huxley.
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1. No object is so beautiful that, under certain conditions, it will not look ugly. - Oscar Wilde
2. God tries you in certain, certain ways. Some people are rich, and they believe in God. They lose the money, things get hard, they get weak and quit going to church. Quit serving God like they did. - Muhammad Ali
3. Certain thoughts are prayers. There are moments when, whatever be the attitude of the body, the soul is on its knees. - Victor Hugo
4. I don't believe one grows older. I think that what happens early on in life is that at a certain age one stands still and stagnates. - T. S. Eliot
5. Curiosity is one of the most permanent and certain characteristics of a vigorous intellect. - Samuel Johnson
6. Each one of us has our own evolution of life, and each one of us goes through different tests which are unique and challenging. But certain things are common. And we do learn things from each other's experience. On a spiritual journey, we all have the same destination. - A. R. Rahman
7. Through perseverance many people win success out of what seemed destined to be certain failure. - Benjamin Disraeli
8. It seems to me we can never give up longing and wishing while we are thoroughly alive. There are certain things we feel to be beautiful and good, and we must hunger after them. - George Eliot
9. Happiness is a state of mind, you know. I don't think you are permanently happy. One is happy about certain things and not so happy about others. - Indira Gandhi
10. The law condemns and punishes only actions within certain definite and narrow limits; it thereby justifies, in a way, all similar actions that lie outside those limits. - Leo Tolstoy
11. Atoms are very special: they like certain particular partners, certain particular directions, and so on. It is the job of physics to analyze why each one wants what it wants. - Richard P. Feynman
12. Change is certain. Peace is followed by disturbances; departure of evil men by their return. Such recurrences should not constitute occasions for sadness but realities for awareness, so that one may be happy in the interim. - Percy Bysshe Shelley.
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1. A person who doubts himself is like a man who would enlist in the ranks of his enemies and bear arms against himself. He makes his failure certain by himself being the first person to be convinced of it. - Alexandre Dumas
2. Certain thoughts are prayers. There are moments when, whatever be the attitude of the body, the soul is on its knees. - Victor Hugo
3. I don't believe one grows older. I think that what happens early on in life is that at a certain age one stands still and stagnates. - T. S. Eliot
4. Wars are, of course, as a rule to be avoided; but they are far better than certain kinds of peace. - Theodore Roosevelt
5. Swans sing before they die - 'twere no bad thing should certain persons die before they sing. - Samuel Taylor Coleridge
6. I'm not really conservative. I'm conservative on certain things. I believe in less government. I believe in fiscal responsibility and all those things that maybe Republicans used to believe in but don't any more. - Clint Eastwood
7. We will have to accept a certain degree of legal immigration; that's globalisation... In the era of the smartphone, we cannot shut ourselves away... people know full well how we live in Europe. - Angela Merkel
8. You can have a certain arrogance, and I think that's fine, but what you should never lose is the respect for the others. - Steffi Graf
9. A doubtful friend is worse than a certain enemy. Let a man be one thing or the other, and we then know how to meet him. - Aesop
10. Curiosity is one of the most permanent and certain characteristics of a vigorous intellect. - Samuel Johnson
11. Mathematics is a game played according to certain simple rules with meaningless marks on paper. - David Hilbert
12. Self-respect, dignity and grace are very important. You may look a certain way or come from a certain background but when you have these three qualities you stand apart from the crowd. - Esha Deol.
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1. Competition has been shown to be useful up to a certain point and no further, but cooperation, which is the thing we must strive for today, begins where competition leaves off. - Franklin D. Roosevelt
2. Some folks look at me and see a certain swagger, which in Texas is called 'walking.' - George W. Bush
3. What is success? I think it is a mixture of having a flair for the thing that you are doing; knowing that it is not enough, that you have got to have hard work and a certain sense of purpose. - Margaret Thatcher
4. We hold these truths to be self-evident: that all men are created equal; that they are endowed by their Creator with certain unalienable rights; that among these are life, liberty, and the pursuit of happiness. - Thomas Jefferson
5. Good advice is always certain to be ignored, but that's no reason not to give it. - Agatha Christie
6. Socialism is... not only a way of life, but a certain scientific approach to social and economic problems. - Jawaharlal Nehru
7. When you put on a uniform, there are certain inhibitions that you accept. - Dwight D. Eisenhower
8. Do the thing we fear, and death of fear is certain. - Ralph Waldo Emerson
9. Of all the things I've done, the most vital is coordinating those who work with me and aiming their efforts at a certain goal. - Walt Disney
10. The problem is when you are writing something in retrospective, it needs a lot of courage not to change, or you will forget a certain reality, and you will just take in consideration your view today. - Boutros Boutros-Ghali
11. If there's one thing that's certain in business, it's uncertainty. - Stephen Covey
12. There may be aliens in our Milky Way galaxy, and there are billions of other galaxies. The probability is almost certain that there is life somewhere in space. - Buzz Aldrin.
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1. The whole problem with the world is that fools and fanatics are always so certain of themselves, and wiser people so full of doubts. - Bertrand Russell
2. Change is the law of life. And those who look only to the past or present are certain to miss the future. - John F. Kennedy
3. There is only one corner of the universe you can be certain of improving, and that's your own self. - Aldous Huxley
4. Focusing your life solely on making a buck shows a certain poverty of ambition. It asks too little of yourself. Because it's only when you hitch your wagon to something larger than yourself that you realize your true potential. - Barack Obama
5. Our greatest weakness lies in giving up. The most certain way to succeed is always to try just one more time. - Thomas A. Edison
6. Do the thing you fear most and the death of fear is certain. - Mark Twain
7. So long as the memory of certain beloved friends lives in my heart, I shall say that life is good. - Helen Keller
8. I am certain of nothing but the holiness of the heart's affections, and the truth of imagination. - John Keats
9. It is certain, in any case, that ignorance, allied with power, is the most ferocious enemy justice can have. - James Baldwin
10. Whatever possession we gain by our sword cannot be sure or lasting, but the love gained by kindness and moderation is certain and durable. - Alexander the Great
11. In this world nothing can be said to be certain, except death and taxes. - Benjamin Franklin
12. There's too much darkness in the world. Everywhere you turn, someone is tryin' to tear someone down in some way; everywhere you go, there's a feeling of inadequacy, or a feeling that you're not good enough. I want to bring a certain light to the world. - Alicia Keys.
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1. I started doing motivational tours. I've seen all kinds of people, from the CEOs to the lowest executive, opening up to their fears. We don't introspect as much as we should. - Anupam Kher
2. I worked with Congress on legislation, gave speeches to CEOs, military generals and Hollywood executives. But I also worked to ensure that my efforts would resonate with kids and families - and that meant doing things in a creative and unconventional way. So, yeah, I planted a garden and hula-hooped on the White House lawn with kids. - Michelle Obama
3. ObamaCare is working. I talk to a lot of CEOs of hospitals. It is working. - Magic Johnson
4. But I did 'Bill & Ted's Excellent Adventure.' They made a cereal out of it, so once you've had a cereal, it doesn't get much more surreal than that. Surreal cereal. - Keanu Reeves
5. I have my hopes, & very distinct ones, too, of one day getting cerebral phenomena such that I can put them into mathematical equations: in short, a law or laws for the mutual actions of the molecules of the brain (equivalent to the law of gravitation for the planetary & sideral world). - Ada Lovelace
6. Much literary criticism comes from people for whom extreme specialization is a cover for either grave cerebral inadequacy or terminal laziness, the latter being a much cherished aspect of academic freedom. - John Kenneth Galbraith
7. Nobody ever thought of me as dumb. They always knew me as cerebral, a thinking person. Educated and so on. But I was always given glamorous roles. - Zeenat Aman.
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1. The path to the CEO's office should not be through the CFO's office, and it should not be through the marketing department. It needs to be through engineering and design. - Elon Musk
2. Just because you are CEO, don't think you have landed. You must continually increase your learning, the way you think, and the way you approach the organization. I've never forgotten that. - Indra Nooyi
3. At the end of the day, if you're a professional athlete in track and field you are the CEO of your company. -
Carl Lewis
4. Any enterprise CEO really ought to be able to ask a question that involves connecting data across the organization, be able to run a company effectively, and especially to be able to respond to unexpected events. Most organizations are missing this ability to connect all the data together. - Tim Berners-Lee
5. America isn't Congress. America isn't Washington. America is the striving immigrant who starts a business, or the mom who works two low-wage jobs to give her kid a better life. America is the union leader and the CEO who put aside their differences to make the economy stronger. - Barack Obama
6. No one person controls Microsoft. The board and the shareholders decide whether they want to have me as CEO. - Bill Gates
7. In my role as executive vice president of development and acquisitions for the Trump Organization and founder and CEO of my own lifestyle brand, I've had a lot of practice negotiating. - Ivanka Trump.
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