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#5875. What does the noun (used with a singular verb) robotics mean?
#5876. What does the adjective robust mean?
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#2828. What does the medical term Stertor mean?
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#9550.
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#6066.
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2385.
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2384.
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#9549.
2380) Pulmonologist
Gist
A pulmonologist is a physician who specializes in the respiratory system. From the windpipe to the lungs, if your complaint involves the lungs or any part of the respiratory system, a pulmonologist is the doc you want to solve the problem. Pulmonology is a medical field of study within internal medicine.
A pulmonologist is a physician who specializes in lung conditions. They diagnose and treat diseases of the respiratory system, including your airways, alveoli (air sacs in your lungs) and blood vessels.
Pulmonology: A branch of medicine that specializes in diagnosing and treating diseases of the lungs and other parts of the respiratory system. These diseases include asthma, emphysema, tuberculosis, and pneumonia.
Summary
A pulmonologist is a healthcare provider that specializes in diagnosing and treating conditions that affect your respiratory system, including your airways and lungs. You might see a pulmonologist if you have a chronic condition that affects your breathing or if you have symptoms like chronic cough, shortness of breath or wheezing.
Overview:
What is a pulmonologist?
A pulmonologist is a physician who specializes in lung conditions. They diagnose and treat diseases of the respiratory system, including your airways, alveoli (air sacs in your lungs) and blood vessels.
You might hear people call pulmonologists lung doctors, lung specialists or chest doctors.
What does a pulmonologist do?
A pulmonologist can diagnose and treat respiratory system diseases. They might have certain areas that they specialize in, like critical care, asthma or sleep medicine. They might also specialize in treating certain age groups, like kids younger than 18 (pediatric pulmonologists) or people over 65 (geriatric pulmonologists).
What conditions do pulmonologists treat?
Pulmonologists treat various respiratory conditions and illnesses, including:
* Asbestosis.
* Aspergillosis.
* Asthma.
* Bronchiectasis.
* Bronchitis.
* Chronic beryllium disease (berylliosis).
* Chronic obstructive pulmonary disease (COPD).
* Coal workers’ pneumoconiosis (black lung disease).
* Cystic fibrosis.
* Emphysema.
* Interstitial lung disease.
* Long COVID.
* Lung cancer.
* Pulmonary hypertension.
* Sarcoidosis.
* Silicosis.
* Sleep apnea.
* Tuberculosis.
Why would you need to see a pulmonologist?
If you have a respiratory condition that requires specialized testing, your primary care provider might refer you to a pulmonologist. Symptoms you might see a pulmonologist for include:
* A cough that doesn’t improve over time (chronic cough).
* Shortness of breath (dyspnea).
* Asthma attacks.
* Chest pain or tightness.
* Wheezing.
* Sleep apnea symptoms, like daytime tiredness or snoring.
What will a pulmonologist do on the first visit?
If it’s your first appointment with a pulmonologist, they’ll take a detailed medical history and do a physical examination. During this time, you can talk with your healthcare provider about the reasons you’re there and explain the details of your symptoms.
You might find it helpful to prepare notes in advance about things like:
* How long you’ve had symptoms.
* If you’ve noticed anything that triggers your symptoms (like respiratory illnesses, stress or seasonal changes).
* Anything you’ve noticed that makes your symptoms better or worse.
* Whether you smoke or vape, or if you used to.
* Whether your job, hobbies or living conditions could’ve exposed to you allergens or lung irritants (like secondhand smoke, chemicals, grains, livestock or birds).
* Whether anyone in your family has a respiratory condition.
* Any questions you have.
Before the end of the appointment, your provider might:
* Order tests.
* Schedule a follow-up visit.
* Recommend or prescribe treatments.
* Refer you to another provider.
What tests does a pulmonologist run?
Your pulmonologist might order some tests to help with diagnosis and treatment. These might include:
* Blood tests.
* Imaging tests like chest X-rays or CT scans (computed tomography scans).
* Pulmonary function tests.
* Spirometry.
* Bronchoscopy.
* Sleep studies.
You may have to repeat these tests in the future or have additional testing to confirm results.
Details
A pulmonologist is a doctor who diagnoses and treats diseases of the respiratory system -- the lungs and other organs that help you breathe.
For some relatively short-lasting illnesses that affect your lungs, like the flu or pneumonia, you might be able to get all the care you need from your regular doctor. But if your cough, shortness of breath, or other symptoms don't get better, you might need to see a pulmonologist.
What is pulmonology?
Internal medicine is the type of medical care that deals with adult health, and pulmonology is one of its many fields. Pulmonologists focus on the respiratory system and diseases that affect it. The respiratory system includes your:
* Mouth and nose
* Sinuses
* Throat (pharynx)
* Voice box (larynx)
* Windpipe (trachea)
* Bronchial tubes
* Lungs and things inside them like bronchioles and alveoli
* Diaphragm
What Conditions Do Pulmonologists Treat?
A pulmonologist can treat many kinds of lung problems. These include:
* Asthma, a disease that inflames and narrows your airways and makes it hard to breathe
* Chronic obstructive pulmonary disease (COPD), a group of lung diseases that includes emphysema and chronic bronchitis
* Cystic fibrosis, a disease caused by changes in your genes that makes sticky mucus build up in your lungs
* Emphysema, which damages the air sacs in your lungs
* Interstitial lung disease, a group of conditions that scar and stiffen your lungs
* Lung cancer, a type of cancer that starts in the lungs
* Obstructive sleep apnea, which causes repeated pauses in your breathing while you sleep
* Pulmonary hypertension, or high blood pressure in the arteries of your lungs
* Tuberculosis, a bacterial infection of the lungs
* Bronchiectasis, which damages your airways so they widen and become flabby or scarred
* Bronchitis, which is when your airways are inflamed, with a cough and extra mucus. It can lead to an infection.
* Pneumonia, an infection that makes the air sacs (alveoli) in your lungs inflamed and filled with pus
* COVID-19 pneumonia, which can cause severe breathing problems and respiratory failure
What Kind of Training Do Pulmonologists Have?
A pulmonologist's training starts with a medical school degree. Then, they do an internal medicine residency at a hospital for 3 years to get more experience. After their residency, doctors can get certified in internal medicine by the American Board of Internal Medicine.
That's followed by years of specialized training as a fellow in pulmonary medicine. Finally, they must pass specialty exams to become board-certified in pulmonology. Some doctors get even more training in Interventional Pulmonary, pulmonary hypertension, and lung transplantation. Others might specialize in younger or older patients.
How Do Pulmonologists Diagnose Lung Diseases?
Pulmonologists use tests to figure out what kind of lung problem you have. They might ask you to get:
* Blood tests. They check levels of oxygen and other things in your blood.
* Bronchoscopy. It uses a thin, flexible tube with a camera on the end to see inside your lungs and airways.
* X-rays. They use low doses of radiation to make images of your lungs and other things in your chest.
* CT scan. It's a powerful X-ray that makes detailed pictures of the inside of your chest.
* Spirometry. This tests how well your lungs work by measuring how hard you can breathe air in and out.
What Kinds of Procedures Do Pulmonologists Do?
Pulmonologists can do special procedures such as:
* Pulmonary hygiene. This clears fluid and mucus from your lungs.
* Airway ablation. This opens blocked air passages or eases difficult breathing.
* Biopsy. This takes tissue samples to diagnose disease.
* Bronchoscopy. This looks inside your lungs and airways to diagnose disease.
Why See a Pulmonologist
You might see a pulmonologist if you have symptoms such as:
* A cough that is severe or that lasts more than 3 weeks
* Chest pain
* Wheezing
* Dizziness
* Trouble breathing
* Severe tiredness
* Asthma that’s hard to control
* Bronchitis or a cold that keeps coming back.
Additional Information
Pulmonology is a medical specialty that deals with diseases involving the respiratory tract. It is also known as respirology, respiratory medicine, or chest medicine in some countries and areas.
Pulmonology is considered a branch of internal medicine, and is related to intensive care medicine. Pulmonology often involves managing patients who need life support and mechanical ventilation. Pulmonologists are specially trained in diseases and conditions of the chest, particularly pneumonia, asthma, tuberculosis, emphysema, and complicated chest infections.
Pulmonology/respirology departments work especially closely with certain other specialties: cardiothoracic surgery departments and cardiology departments.
History of pulmonology
One of the first major discoveries relevant to the field of pulmonology was the discovery of pulmonary circulation. Originally, it was thought that blood reaching the right side of the heart passed through small 'pores' in the septum into the left side to be oxygenated, as theorized by Galen; however, the discovery of pulmonary circulation disproves this theory, which had previously been accepted since the 2nd century. Thirteenth-century anatomist and physiologist Ibn Al-Nafis accurately theorized that there was no 'direct' passage between the two sides (ventricles) of the heart. He believed that the blood must have passed through the pulmonary artery, through the lungs, and back into the heart to be pumped around the body. This is believed by many to be the first scientific description of pulmonary circulation.
Although pulmonary medicine only began to evolve as a medical specialty in the 1950s, William Welch and William Osler founded the 'parent' organization of the American Thoracic Society, the National Association for the Study and Prevention of Tuberculosis. The care, treatment, and study of tuberculosis of the lung is recognised as a discipline in its own right, phthisiology. When the specialty did begin to evolve, several discoveries were being made linking the respiratory system and the measurement of arterial blood gases, attracting more and more physicians and researchers to the developing field.
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#6065.
Q: Why did the cabbage win the race?
A: Because it was ahead!
* * *
Q: Why were the baby strawberries crying?
A: Their ma and pa were in a jam.
* * *
Q: What kind of vegetable do you get when an elephant walks through your garden?
A: Squash.
* * *
Q: Why was the cucumber mad?
A: Because it was in a pickle!
* * *
Q: What grows when fed but dies when watered?
A: Fire.
* * *
Q: Why did the tomato blush?
A: Because he saw the salad dressing!
* * *
City Quotes - VIII
1. Throughout my 20s and early 30s, I had jobs that I loved. I worked in city government. I ran a youth organization. I served as an associate dean at a university. And I couldn't imagine how a baby would fit into all of that. - Michelle Obama
2. I think Star City should have Unesco World Heritage status. It will need to be adapted a little bit and made more glamorous than it looks now, but it should definitely be protected for the future. - Valentina Tereshkova
3. I've shot many films in Hindi and some in Bangla in Kolkata. It's always a pleasure to be part of the city. - Waheeda Rehman
4. London is the most commercially important city in Europe, and it's the most populous city. It should be for the whole of the European continent what New York is to America. That's what it should be. - Boris Johnson
5. The country's top chefs, designers, media personalities and businesses are part of this dynamic city. We know that Chicagoans are used to the highest standards. - Ivanka Trump
6. I'd like to design something like a city or a museum. I want to do something hands on rather than just play golf which is the sport of the religious right. - Brad Pitt
7. You can't have a relationship when you're shooting a 14-hour day and your husband is shooting a 14-hour day in the same city. It's a time thing and it's a together thing. - Eva Longoria.
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#9548.
Hi,
#6064.
Hi,
2383.
Rainbow
Gist
When sunlight hits a rain droplet, some of the light is reflected. The electromagnetic spectrum is made of light with many different wavelengths, and each is reflected at a different angle. Thus, spectrum is separated, producing a rainbow.
VIBGYOR (Violet–Indigo–Blue–Green–Yellow–Orange–Red) is a popular mnemonic device used for memorizing the traditional optical spectrum.
A rainbow has seven colors because water droplets in the atmosphere break sunlight into seven colors. A prism similarly divides light into seven colors. When light leaves one medium and enters another, the light changes its propagation direction and bends. This is called refraction.
When sunlight hits a rain droplet, some of the light is reflected. The electromagnetic spectrum is made of light with many different wavelengths, and each is reflected at a different angle. Thus, spectrum is separated, producing a rainbow.
Summary
A rainbow is an optical phenomenon caused by refraction, internal reflection and dispersion of light in water droplets resulting in a continuous spectrum of light appearing in the sky. The rainbow takes the form of a multicoloured circular arc. Rainbows caused by sunlight always appear in the section of sky directly opposite the Sun. Rainbows can be caused by many forms of airborne water. These include not only rain, but also mist, spray, and airborne dew.
Rainbows can be full circles. However, the observer normally sees only an arc formed by illuminated droplets above the ground,[3] and centered on a line from the Sun to the observer's eye.
In a primary rainbow, the arc shows red on the outer part and violet on the inner side. This rainbow is caused by light being refracted when entering a droplet of water, then reflected inside on the back of the droplet and refracted again when leaving it.
In a double rainbow, a second arc is seen outside the primary arc, and has the order of its colours reversed, with red on the inner side of the arc. This is caused by the light being reflected twice on the inside of the droplet before leaving it.
Visibility
Rainbows can be observed whenever there are water drops in the air and sunlight shining from behind the observer at a low altitude angle. Because of this, rainbows are usually seen in the western sky during the morning and in the eastern sky during the early evening. The most spectacular rainbow displays happen when half the sky is still dark with raining clouds and the observer is at a spot with clear sky in the direction of the Sun. The result is a luminous rainbow that contrasts with the darkened background. During such good visibility conditions, the larger but fainter secondary rainbow is often visible. It appears about 10° outside of the primary rainbow, with inverse order of colours.
The rainbow effect is also commonly seen near waterfalls or fountains. In addition, the effect can be artificially created by dispersing water droplets into the air during a sunny day. Rarely, a moonbow, lunar rainbow or nighttime rainbow, can be seen on strongly moonlit nights. As human visual perception for colour is poor in low light, moonbows are often perceived to be white.
It is difficult to photograph the complete semicircle of a rainbow in one frame, as this would require an angle of view of 84°. For a 35 mm camera, a wide-angle lens with a focal length of 19 mm or less would be required. Now that software for stitching several images into a panorama is available, images of the entire arc and even secondary arcs can be created fairly easily from a series of overlapping frames.
From above the Earth such as in an aeroplane, it is sometimes possible to see a rainbow as a full circle. This phenomenon can be confused with the glory phenomenon, but a glory is usually much smaller, covering only 5–20°.
The sky inside a primary rainbow is brighter than the sky outside of the bow. This is because each raindrop is a sphere and it scatters light over an entire circular disc in the sky. The radius of the disc depends on the wavelength of light, with red light being scattered over a larger angle than blue light. Over most of the disc, scattered light at all wavelengths overlaps, resulting in white light which brightens the sky. At the edge, the wavelength dependence of the scattering gives rise to the rainbow.
The light of a primary rainbow arc is 96% polarised tangential to the arc. The light of the second arc is 90% polarised.
Details
A rainbow is a multicolored arc made by light striking water droplets.
The most familiar type rainbow is produced when sunlight strikes raindrops in front of a viewer at a precise angle (42 degrees). Rainbows can also be viewed around fog, sea spray, or waterfalls.
A rainbow is an optical illusion—it does not actually exist in a specific spot in the sky. The appearance of a rainbow depends on where you're standing and where the sun (or other source of light) is shining.
The sun or other source of light is usually behind the person seeing the rainbow. In fact, the center of a primary rainbow is the antisolar point, the imaginary point exactly opposite the sun.
Rainbows are the result of the refraction and reflection of light. Both refraction and reflection are phenomena that involve a change in a wave's direction. A refracted wave may appear "bent," while a reflected wave might seem to "bounce back" from a surface or other wavefront.
Light entering a water droplet is refracted. It is then reflected by the back of the droplet. As this reflected light leaves the droplet, it is refracted again, at multiple angles.
The radius of a rainbow is determined by the water droplets' refractive index. A refractive index is the measure of how much a ray of light refracts (bends) as it passes from one medium to another—from air to water, for example. A droplet with a high refractive index will help produce a rainbow with a smaller radius. Saltwater has a higher refractive index than freshwater, for instance, so rainbows formed by sea spray will be smaller than rainbows formed by rain.
Rainbows are actually full circles. The antisolar point is the center of the circle. Viewers in aircraft can sometimes see these circular rainbows.
Viewers on the ground can only see the light reflected by raindrops above the horizon. Because each person's horizon is a little different, no one actually sees a full rainbow from the ground. In fact, no one sees the same rainbow—each person has a different antisolar point, each person has a different horizon. Someone who appears below or near the "end" of a rainbow to one viewer will see another rainbow, extending from his or her own horizon.
Colors
A rainbow shows up as a spectrum of light: a band of familiar colors that include red, orange, yellow, green, blue, and violet. The name "Roy G. Biv" is an easy way to remember the colors of the rainbow, and the order in which they appear: red, orange, yellow, green, blue, indigo, and violet. (Many scientists, however, think "indigo" is too close to blue to be truly distinguishable.)
White light is how our eyes perceive all the colors of the rainbow mixed together. Sunlight appears white.
When sunlight hits a rain droplet, some of the light is reflected. The electromagnetic spectrum is made of light with many different wavelengths, and each is reflected at a different angle. Thus, spectrum is separated, producing a rainbow.
Red has the longest wavelength of visible light, about 650 nanometers. It usually appears on the outer part of a rainbow's arch. Violet has the shortest wavelength (about 400 nanometers) and it usually appears on the inner arch of the rainbow.
At their edges, the colors of a rainbow actually overlap. This produces a sheen of "white" light, making the inside of a rainbow much brighter than the outside.
Visible light is only part of a rainbow. Infrared radiation exists just beyond visible red light, while ultraviolet is just beyond violet. There are also radio waves (beyond infrared), x-rays (beyond ultraviolet), and gamma radiation (beyond x-rays). Scientists use an instrument called a spectrometer to study these invisible parts of the rainbow.
Rainbow Variations:
Glow
The atmosphere opposite a rainbow, facing the sun, is often glowing. This glow appears when rain or drizzle is falling between the viewer and the sun.
The glow is formed by light passing through raindrops, not reflected by them. Some scientists call this glow a zero-order glow.
Double Rainbow
Sometimes, a viewer may see a "double rainbow." In this phenomenon, a faint, secondary rainbow appears above the primary one.
Double rainbows are caused by light being reflected twice inside the raindrop. As a result of this second reflection, the spectrum of the secondary rainbow is reversed: red is on the inner section of the arch, while violet is on the outside.
Higher-Order Rainbows
Light can be reflected from many angles inside the raindrop. A rainbow's "order" is its reflective number. (Primary rainbows are first-order rainbows, while secondary rainbows are second-order rainbows.) Higher-order rainbows appear to viewers facing both toward and away from the sun.
A tertiary rainbow, for example, appears to a viewer facing the sun. Tertiary rainbows are third-order rainbows—the third reflection of light. Their spectrum is the same as the primary rainbow.
Tertiary rainbows are difficult to see for three main reasons. First, the viewer is looking toward the sun—the center of a tertiary rainbow is not the antisolar point, it's the sun itself. Second, tertiary rainbows are much, much fainter than primary or secondary rainbows. Finally, tertiary rainbows are much, much broader than primary and secondary rainbows.
Quaternary rainbows are fourth-order rainbows, and also appear to viewers facing the sun. They are even fainter and broader than tertiary rainbows.
Beyond quaternary rainbows, higher-order rainbows are named by their reflective number, or order. In the lab, scientists have detected a 200th-order rainbow.
Twinned Rainbow
A twinned rainbow is two distinct rainbows produced from a single endpoint. Twinned rainbows are the result of light hitting an air mass with different sizes and shapes of water droplets—usually a raincloud with different sizes and shapes of raindrops.
Supernumerary Rainbow
A supernumerary rainbow is a thin, pastel-colored arc usually appearing below the inner arch of a rainbow. Supernumeraries are the result of the complex interaction of light rays in an air mass with small, similarly sized water droplets.
In supernumerary formation, reflected rays interact in ways called constructive and destructive interference. Light is either reinforced (constructive interference) or canceled out (destructive interference). Interference is responsible for the lighter hues and narrower bands of supernumeraries.
Reflection Rainbow
A reflection rainbow appears above a body of water. A primary rainbow is reflected by the water, and the reflected light produces a reflection rainbow. Reflection rainbows do not mirror the primary rainbow—they often appear to stretch above it.
Reflected Rainbow
A reflected rainbow appears directly on the surface of a body of water. A reflected rainbow is created by rays of light reflected by the water surface, after the rays have have passed through water droplets. Reflected rainbows to not appear to form a circle with a primary rainbow, although their endpoints seem to meet in an almond-shaped formation.
Red Rainbow
A red rainbow, also called a monochrome rainbow, usually appears at sunrise or sunset. During this time, sunlight travels further in the atmosphere, and shorter wavelengths (blue and violet) have been scattered. Only the long-wavelength red colors are visible in this rainbow.
Fogbow
A fogbow is formed in much the same way as a primary rainbow. Light in a fogbow is refracted and reflected by fog (water droplets suspended in air). A fogbow seen in the clouds is called a cloudbow.
Because the water droplets in fog are much smaller than raindrops, fogbows have much fainter colors than rainbows. In fact, some fogbows have few detectable colors at all and appear mostly white, with a reddish tinge on their outer edge and a bluish tinge on their inner edge.
Moonbow
A moonbow, also called a lunar rainbow, is a rainbow produced by light reflected by the moon.
The moon itself does not emit light, of course. Moonlight is reflected sunlight, as well as some starlight and "Earthlight." Because moonlight is so much fainter than sunlight, moonbows are dimmer than rainbows.
Rainbows in Myth
Rainbows are part of the myths of many cultures around the world. Rainbows are often portrayed as bridges between people and supernatural beings. In Norse mythology, for instance, a rainbow called the Bifrost connects Earth with Asgard, where the gods live. In the ancient beliefs of Japan and Gabon, rainbows were the bridges that human ancestors took to descend to the planet.
The shape of a rainbow also resembles the bow of an archer. Hindu culture teaches that the god Indra uses his rainbow bow to shoot arrows of lightning.
Rainbows are usually positive symbols in myths and legends. In the Epic of Gilgamesh and, later, the Christian Bible, the rainbow is a symbol from a deity (the goddess Ishtar and the Hebrew God) to never again destroy Earth with floods.
Sometimes, however, rainbows are negative symbols. In parts of Burma, for instance, rainbows are considered demons that threaten children. Tribes throughout the Amazon Basin associate rainbows with disease.
Perhaps the most famous piece of mythology surrounding rainbows is the Irish legend of the pot of gold at the end of a rainbow. The gold is guarded by a tricky leprechaun, but—because no one sees the same rainbow and rainbows don't "end" (they're circles)—no one ever finds the gold or the magical creature.
Rainbow Flags
Rainbow flags usually appear as stripes (bands) of at least five different colors. Rainbow flags have long represented groups championing diversity, respect, and inclusiveness.
The Wiphala is a type of rainbow flag. It is a symbol of communities indigenous to the Andes, stretching from modern-day Ecuador to Chile. A Wiphala has been an official flag of Bolivia since 2009, when the nation elected its first indigenous president, Evo Morales. The Wiphala features a diagonal patchwork design with squares in different rainbow colors. Different arrangements of patchwork squares represent different Andean communities.
The Buddhist flag, designed in the 19th century, is flown by Buddhists around the world. It is a vertical arrangement of six bands, each representing a different aspect of Buddhism, from kindness to moderation, blessings to wisdom.
The Jewish Autonomous Oblast, a community on Russia's border with China, is represented by a seven-banded rainbow flag. The seven bands symbolize the seven branches of a menorah.
Additional Information - I
A rainbow is a series of concentric coloured arcs that may be seen when light from a distant source—most commonly the Sun—falls upon a collection of water drops—as in rain, spray, or fog. The rainbow is observed in the direction opposite to the Sun.
The coloured rays of the rainbow are caused by the refraction and internal reflection of light rays that enter the raindrop, each colour being bent through a slightly different angle. Hence, the composite colours of the incident light will be separated upon emerging from the drop. The most brilliant and most common rainbow is the so-called primary bow, which results from light that emerges from the drop after one internal reflection.
Although light rays may exit the drop in more than one direction, a high density of the rays emerge at a minimum angle of deviation from the direction of the incoming rays. The observer thus sees the highest intensity looking at the rays that have minimum deviation, which form a cone with the vertex in the observer’s eye and with the axis passing through the Sun. Light emerging from raindrops after one internal reflection has a minimum deviation of about 138° and thus the greatest intensity in the directions forming a cone with an angular radius of about 42°, with arcs (from inside to outside) of violet, indigo, blue, green, yellow, orange, and red.
Occasionally, a secondary bow may be observed, which is considerably less intense than the primary bow and has its colour sequence reversed. The secondary rainbow has an angular radius of about 50° and hence is seen outside of the primary bow. This bow results from light that has undergone two internal reflections within the water drop. Higher-order rainbows, resulting from three or more internal reflections, are exceedingly weak and hence are rarely observed.
Occasionally, faintly coloured rings are seen just inside of the primary bow. These are called supernumerary rainbows; they owe their origin to interference effects on the light rays emerging from the water droplet after one internal reflection.
Additional Information - II
A rainbow is a multicolored arc, or curved line, in the sky. Most rainbows form when the Sun’s rays strike raindrops falling from faraway rain clouds. Rainbows appear in the part of the sky opposite the Sun, usually in the early morning or late afternoon. From inside to outside, the colors of a rainbow are violet, indigo, blue, green, yellow, orange, and red.
Sunlight travels through space in the form of waves. Scientists use an idea called wavelength to describe these waves. Some light waves have long wavelengths, while others have short wavelengths. Light waves with different wavelengths appear as different colors. Usually all light waves blend together to form white light. But when light waves pass through raindrops, they separate. This happens because the raindrops bend light waves with different wavelengths by a different amount. The separated light waves appear as the colors of a rainbow.
The brightest and most common type of rainbow is called a primary bow. Sometimes a fainter rainbow forms outside the primary bow. This is called a secondary bow or, sometimes, a double rainbow. A secondary bow forms when the light bends twice inside the water drops. The first bend makes the primary bow, and the second bend makes the secondary bow. The colors in the secondary bow appear in the opposite order of the colors in the primary bow.
Pheniramine
Gist
Pheniramine is an antihistamine used to treat allergic rhinitis and pruritus. Naphcon A, Opcon-A, Visine-A. Generic Name Pheniramine DrugBank Accession Number DB01620 Background. Pheniramine is a first-generation antihistamine in the alkylamine class, similar to brompheniramine and chlorpheniramine.
Pheniramine is an 'anti-allergy' medication which contains 'Pheniramine' primarily used to treat allergic conditions. It helps treat allergy-like runny nose, sneezing, congestion, itching, and watery eyes. It is also used to avoid or relieve motion sickness, nasal congestion, and allergic skin irritation.
Summary
Pheniramine is an antihistamine medication used to treat allergic conditions such as hay fever and hives. It works by blocking the effects of histamine, a chemical produced by the body in response to allergens.
What is pheniramine?
Pheniramine is an antihistamine medication that is used to treat symptoms of allergies, such as itching, sneezing, and runny nose.
How does pheniramine work?
Pheniramine blocks the effects of histamine, a chemical released by the body in response to allergens, which helps to reduce allergy symptoms.
What are some side effects of pheniramine?
Common side effects of pheniramine include drowsiness, dry mouth, and blurred vision. Rare but serious side effects can include seizures and irregular heartbeat.
Can pheniramine be used to treat all types of allergies?
Pheniramine is most effective in treating allergies caused by histamine, such as hay fever and allergic rhinitis. It may be less effective in treating allergies caused by other substances, such as food or insect stings.
Is pheniramine safe for everyone to use?
Pheniramine may not be safe for everyone to use, particularly people with certain medical conditions or those taking certain medications. It is important to talk to a doctor before taking pheniramine to ensure that it is safe and appropriate for you.
What are the recommended doses of pheniramine for allergies?
The recommended doses of pheniramine for allergies vary depending on age, weight, and medical history. It is important to follow the instructions on the label or as directed by a healthcare professional.
Is pheniramine available over-the-counter or by prescription only?
Pheniramine is generally available over-the-counter.
Are there any foods or medications that should be avoided while taking pheniramine?
Pheniramine can interact with certain foods and medications, including alcohol and sedatives. It is important to talk to a doctor or pharmacist about any potential interactions before taking pheniramine.
What are some alternative treatments for allergies if pheniramine is not effective or not suitable for a person?
There are several alternative treatments for allergies, including other antihistamines, nasal corticosteroids, and immunotherapy. A healthcare professional can recommend the best treatment options based on an individual's specific needs and medical history.
Details
Pheniramine (trade name Avil among others) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It has relatively strong sedative effects, and may sometimes be used off-label as an over-the-counter sleeping pill in a similar manner to other sedating antihistamines such as diphenhydramine. Pheniramine is also commonly found in eyedrops used for the treatment of allergic conjunctivitis.
It was patented in 1948. Pheniramine is generally sold in combination with other medications, rather than as a stand-alone drug, although some formulations are available containing pheniramine by itself.
Side effects
Pheniramine may cause drowsiness or Tachycardia, and over-dosage may lead to sleep disorders.
Overdose may lead to seizures, especially in combination with alcohol.
People combining with cortisol in the long term should avoid pheniramine as it may decrease levels of adrenaline (epinephrine) which may lead to loss of consciousness.
Pheniramine is a deliriant (hallucinogen) in toxic doses. Recreational use of Coricidin for the dissociative (hallucinogenic) effect of its dextromethorphan is hazardous because it also contains chlorpheniramine.
Chemical relatives
Halogenation of pheniramine increases its potency 20-fold. Halogenated derivatives of pheniramine include chlorphenamine, brompheniramine, dexchlorpheniramine, dexbrompheniramine, and zimelidine. Two other halogenated derivatives, fluorpheniramine and iodopheniramine, are currently in use for research on combination therapies for malaria and some cancers.
Other analogs include diphenhydramine, and doxylamine.
Stereoisomerism
Pheniramine contains a stereocenter and can exists as either of two enantiomers. The pharmaceutical drug is a racemate, an equal mixture of the (R)- and (S)-forms.
2183) Michael Rosbash
Gist:
Life
Michael Rosbash was born in Kansas City, Missouri, and grew up in Boston, Massachusetts. His parents were of Jewish descent and had fled from Nazi Germany in 1938. He studied at the California Institute of Technology in Pasadena and at Biologie Physico-Chimique in Paris and then obtained a doctor’s degree at the Massachusetts Institute of Technology in 1970. After spending three years at the University of Edinburgh in United Kingdom, he began work in 1974 at Brandeis University in Waltham, Massachusetts. Michael Rosbash is married and has a stepdaughter and a daughter.
Work
In our cells an internal clock helps us to adapt our biological rhythm to the different phases of day and night. Jeffrey Hall, Michael Rosbash and Michael Young studied fruit flies to figure out how this clock works. In 1984 they managed to identify a gene that encodes a protein that accumulates during the night but is degraded during the day. They also identified additional proteins that form part of a self-regulating biological clockwork in the fruit fly's cells. The same principles have been shown to apply to other animals and plants.
Summary
Michael Rosbash (born March 7, 1944, Kansas City, Missouri) is an American geneticist known for his discoveries concerning circadian rhythm, the cyclical 24-hour period of biological activity that drives daily behavioral patterns. Rosbash worked extensively with the fruit fly Drosophila melanogaster, and he contributed to the discovery of genes and molecular mechanisms involved in the regulation of biological rhythms. The work had far-reaching implications, particularly for understanding the influence of genetic cues on daily physiological processes in humans. For his discoveries, he was awarded the 2017 Nobel Prize for Physiology or Medicine (shared with Jeffrey C. Hall and Michael W. Young).
Rosbash was raised in Boston, where his mother worked in cytology and his father was a cantor. He studied chemistry at the California Institute of Technology, receiving a bachelor’s degree in 1965, and biophysics at the Massachusetts Institute of Technology (MIT), graduating with a Ph.D. in 1971. He joined the faculty at Brandeis University in Waltham, Massachusetts, as an assistant professor in 1974.
In the 1970s Rosbash became interested in the influence of genetics on behaviour and began a productive collaboration with Hall, a friend and colleague at Brandeis. Rosbash and Hall were interested in the so-called period gene, a gene that had been discovered a decade earlier to play a role in the regulation of circadian rhythm in Drosophila but that had not yet been isolated from the fruit fly genome. In 1984, at about the same time as Young, who was working independently at Rockefeller University in New York, Rosbash and Hall successfully isolated and sequenced the period gene.
In the 1990s Rosbash and Hall shed light on the mechanistic role of the period gene, showing that levels of the protein product, PER, oscillated during the circadian cycle, accumulating in cell nuclei overnight and being degraded through the day. Their findings led them to propose a model whereby PER was self-regulating, inhibiting its own transcription (synthesis of RNA from DNA) when its protein levels reached a critical point. Rosbash and Hall subsequently discovered additional genes involved in the regulation of the circadian rhythm. Their later work, along with that of Young and other researchers in the field, helped confirm the idea that a self-regulating clocklike mechanism governs circadian rhythm. A significant number of human genes were subsequently found to be regulated by a mechanism homologous to that described in Drosophila, leading to new insights into human physiology.
Rosbash received numerous honours throughout his career, including the Gruber Prize in Neuroscience (2009), the Louisa Gross Horwitz Prize for Biology or Biochemistry (2011), and the Wiley Prize in Biomedical Sciences (2013), all shared with Hall and Young. He was an elected member of the American Academy of Arts and Sciences (1997) and the National Academy of Sciences (2003).
Details
Michael Morris Rosbash (born March 7, 1944) is an American geneticist and chronobiologist. Rosbash is a professor and researcher at Brandeis University and investigator at the Howard Hughes Medical Institute. Rosbash's research group cloned the Drosophila period gene in 1984 and proposed the Transcription Translation Negative Feedback Loop for circadian clocks in 1990. In 1998, they discovered the cycle gene, clock gene, and cryptochrome photoreceptor in Drosophila through the use of forward genetics, by first identifying the phenotype of a mutant and then determining the genetics behind the mutation. Rosbash was elected to the National Academy of Sciences in 2003. Along with Michael W. Young and Jeffrey C. Hall, he was awarded the 2017 Nobel Prize in Physiology or Medicine "for their discoveries of molecular mechanisms controlling the circadian rhythm".
Life
Michael Rosbash was born in Kansas City, Missouri. His parents, Hilde and Alfred Rosbash, were Jewish refugees who left Nazi Germany in 1938.[5] His father was a cantor, which, in Judaism, is a person who chants worship services. Rosbash's family moved to Boston when he was two years old, and he has been an avid Red Sox fan ever since.
Initially, Rosbash was interested in mathematics but an undergraduate biology course at the California Institute of Technology (Caltech) and a summer of working in Norman Davidson's lab steered him towards biological research. Rosbash graduated from Caltech in 1965 with a degree in chemistry, spent a year at the Institut de Biologie Physico-Chimique in Paris on the Fulbright Scholarship, and obtained a doctoral degree in biophysics in 1970 from the Massachusetts Institute of Technology under Sheldon Penman. After spending three years on a postdoctoral fellowship in genetics at the University of Edinburgh, Rosbash joined the Brandeis University faculty in 1974.
Rosbash is married to fellow scientist Nadja Abovich and he has a stepdaughter named Paula and daughter named Tanya.[6]
Research
Rosbash's research initially focused on the metabolism and processing of mRNA; mRNA is the molecular link between DNA and protein. After arriving at Brandeis, Rosbash collaborated with co-worker Jeffrey Hall and investigated the genetic influences on circadian rhythms of the internal biological clock. They used Drosophila melanogaster to study patterns of activity and rest. In 1984, Rosbash and Hall cloned the first Drosophila clock gene, period. Following work done by post-doctoral fellow, Paul Hardin, in discovering that period mRNA and its associated protein (PER) had fluctuating levels during the circadian cycle, in 1990 they proposed a Transcription Translation Negative Feedback Loop (TTFL) model as the basis of the circadian clock. Following this proposal, they looked into the elements that make up other parts of the clock. In May 1998, Rosbash et al. found a homolog for mammalian Clock that performed the same function of activating the transcription of per and tim that they proceeded to call dClock. Also in May 1998, Rosbash et al. discovered in Drosophila the clock gene cycle, a homolog of the mammalian bmal1 gene. In November 1998, Rosbash et al. discovered the cryb Drosophila mutant, which led to the conclusion that cryptochrome protein is involved in circadian photoreception.
Chronology of major discoveries
1984: Cloned the Drosophila period gene
1990: Proposed the Transcription Translation Negative Feedback Loop for circadian clocks
1998: Identified the Drosophila Clock Gene
1998: Identified the Drosophila Cycle Gene
1998: Identified cryptochrome as a Drosophila Circadian Photoreceptor
1999: Identified LNV Neurons as the Principal Drosophila Circadian Pacemaker
mRNA research
Rosbash began studying mRNA processing as a graduate student at Massachusetts Institute of Technology. His work in the Saccharomyces cerevisiae has revealed the enzymes, proteins, and subcellular organelles and their convergence upon mRNA in a specific order in order to translate mRNA into proteins. Missteps in this process have been linked to diseases such as Alzheimer's disease, so this work is essential for better understanding and treatment of diseases.
Discovery of circadian TTFL in Drosophila
In 1990, Rosbash, Hall, and Hardin discovered the role of the period gene (per) in the Drosophila' circadian oscillator. They found that PER protein levels fluctuate in light dark cycles, and these fluctuations persist in constant darkness. Similarly, per mRNA abundance also has rhythmic expression that entrains to light dark cycles. In the fly head, per mRNA levels oscillate in both 12-hour light, 12-hour dark cycles as well as in constant darkness. Per mRNA levels peaked at the beginning of the subjective night followed by a peak in PER protein levels about 6 hours later. Mutated per genes affected the cycling of per mRNA. From this experimental data, Rosbash, Hall, and Hardin hypothesized that PER protein is involved in a negative feedback loop that controls per mRNA levels, and that this transcription-translation feedback loop is a central feature of the Drosophila circadian clock.
They also looked at two other single missense period mutations, perS and perL1. These mutations cause the peak of the evening activity to occur earlier and later, respectively, compared to wildtype per+ flies. They found that RNA levels for perS and perL1 also display clear rhythmicity. Like locomotor activity the peak expression is shifted earlier for perS and later for perL1.
They transformed the period0 null mutation flies with a 7.2-kb piece of functional per DNA, and measured per mRNA levels at the per0 locus and new locus. Following transformation, per mRNA levels were rhythmic at both the original and new locus. The per0 locus was able to transcribe normal per mRNA and translate normal PER protein, meaning that rhythmicity was rescued by functional PER protein transcribed and translated from the 7.2-kb piece of per DNA. There is a feedback loop at play in which cycling of PER protein levels at the new locus feeds back to dictate cycling of per mRNA levels at the original per0 locus.[8] In 1992, Rosbash again collaborated with Jeffrey Hall and Paul Hardin to more closely examine the mechanisms of the TTFL. They wondered specifically about the regulation of period mRNA level fluctuations, and found that per mRNA levels were transcriptionally regulated. This was supported by the evidence that per precursor RNA cycles with the same phase as mature transcripts, and oscillate with respect to Zeitgeber Time (ZT). Other evidence for transcriptional regulation is that per gene promoter is sufficient to confer cycling to heterologous mRNA.
Challenges to the TTFL model in Drosophila
The Akhilesh Reddy group has shown, using a range of unbiased -omics techniques (RNA-sequencing, proteomics, metabolomics) that Drosophila S2 cells display circadian molecular rhythms. These cells do not express known "clock genes" including per and tim. Introduction of PER and TIM proteins into the cells does not cause rhythmicity of these cells as read out by abundance or phosphorylation of PER and TIM proteins. These cells were thus regarded as "clock-less" by the fly field until now. These findings substantiate the work above in demonstrating the TTFL model of the fly clockwork cannot explain the generation of circadian rhythms.
Discovery of Drosophila Clock Gene
A likely homolog of the previously discovered mouse gene Clock was identified by Rosbash et al. by cloning of the Drosophila gene defined by the Jrk mutation. This gene was given the name Drosophila Clock. dClock has been shown to interact directly with the per and tim E-boxes and contributes to the circadian transcription of these genes. The Jrk mutation disrupts the transcription cycling of per and tim. It also results in completely arrhythmic behavior in constant darkness for homozygous mutants and about half demonstrated arrhythmic behavior in heterozygotes. The Jrk homozygotes expressed low, non-cycling levels of per and tim mRNA as well as PER and TIM protein. From this, it was concluded that the behavioral arrhythmicity in Jrk was due to a defect in the transcription of the per and tim. This indicated that dClock was involved in the transcriptional activation of per and tim.
Discovery of Drosophila Cycle Gene
In 1998, Rosbash et al. discovered the novel clock gene cycle, a homolog of the mammalian Bmal1 gene. Homozygous cycle0 mutants are arrhythmic in locomotor activity and heterozygous cycle0/+ flies have robust rhythms with an altered period of rhythmicity. Western blot analysis shows that homozygous cycle0 mutants have very little PER and TIM protein as well as low per and tim mRNA levels. This indicates that lack of cycle leads to decreased transcription of per and tim genes. Meiotic mapping placed cyc on the third chromosome. They discovered bHLH-PAS domains in cyc, indicating protein binding and DNA binding functions.
Discovery of cryptochrome as a Drosophila circadian photoreceptor
In 1998, Rosbash et al. discovered a Drosophila mutant exhibiting flat, non-oscillating levels of per and tim mRNA, due to a null mutation in the cryptochrome gene. This mutation was dubbed crybaby, or cryb. The failure of cryb mutants to synchronize to light dark cycles indicates that cryptochrome’s normal function involves circadian photoreception.
LNV neurons as principal Drosophila circadian pacemaker
In Drosophila, certain lateral neurons (LNs) have been shown to be important for circadian rhythms, including dorsal (LNd) and ventral (LNV) neurons. LNV neurons express PDF (pigment dispersion factor), which was initially hypothesized to be a clock output signal. Mutants for the pdf neuropeptide gene (pdf01) as well as flies selectively ablated for LNV produced similar behavioral responses. Both entrained to external light cues, but were largely arrhythmic in constant conditions. Some flies in each cases showed weak free-running rhythmicity. These results led the researchers to believe that LNV neurons were the critical circadian pacemaker neurons and that PDF was the principal circadian transmitter.
Current research
In more recent years, Rosbash has been working on the brain-neuronal aspects of circadian rhythms. Seven anatomically distinct neuronal groups have been identified that all express the core clock genes. However, the mRNAs appear to be expressed in a circadian and neuron-specific manner, for which his lab has taken interest in determining whether this provides a link to the distinct functions of certain neuronal groups. He has also researched the effects of light on certain neuronal groups and has found that one subgroup is light-sensitive to lights on (dawn) and another is light-sensitive to lights off (dusk). The dawn cells have been shown to promote arousal while the dusk cells promote sleep.
Today, Rosbash continues to research mRNA processing and the genetic mechanisms underlying circadian rhythms. He has also published an amusing reflection on his life in science.
Hi,
#10285. When is the Hindi Day celebrated?
#10286. International Day of Persons with Disabilities is an international observance promoted by the United Nations since 1992. It has been observed with varying degrees of success around the planet. The observance of the Day aims to promote an understanding of disability issues and mobilize support for the dignity, rights and well-being of persons with disabilities. It also seeks to increase awareness of gains to be derived from the integration of persons with disabilities in every aspect of political, social, economic and cultural life. It was originally called "International Day of Disabled Persons" until 2007. Each year the day focuses on a different issue.
When is it?
Hi,
#5873. What does the adjective scraggly mean?
#5874. What does the verb (used without object) scramble mean?
Hi,
#2827. What does the medical term Psychomotor retardation mean?
Hi,
#9547.
Hi,
#6063.
Hi,
2382.
City Quotes - VII
1. We fixed on No. 4, Queen Street Place, for our City offices, and it was from there that so many of my patented inventions were dated. - Henry Bessemer
2. My passion for the game comes from the city of Marseille itself. Unfortunately I can't go back there as much I want to because I play a lot here and abroad. - Zinedine Zidane
3. As a child, I personally didn't really get to know any Jews. I was eight years old when the Night of Broken Glass happened. And Ludwigshafen was purely a workers' city, so we didn't have a very big Jewish community. What I did know about the Jews, I heard from my mother. My mother was very much pro-Jewish. - Helmut Kohl
4. We have soon to have everywhere smoke annihilators, dust absorbers, ozonizers, sterilizers of water, air, food and clothing, and accident preventers on streets, elevated roads and in subways. It will become next to impossible to contract disease germs or get hurt in the city, and country folk will got to town to rest and get well. - Nikola Tesla
5. I go to London, my favourite city in the world, and I feel at home. - Boris Becker
6. Kids in the city can play cricket, badminton, tennis or football. Athletics is not their cup of tea. - Milkha Singh
7. I want London to be the most cycle-friendly city on Earth, and I want more people to be happy and safe on bicycles. - Boris Johnson
8. Chennai is a beautiful city; I love the roads here and also know the routes. But one tip for car/bike enthusiasts - your life is most important; so, drive safe! - Suresh Raina.
Hi,
2381.